Side Effects: Substantial Non-Neutral Evolution Flanking Regulatory Sites
نویسندگان
چکیده
منابع مشابه
Side Effects: Substantial Non-Neutral Evolution Flanking Regulatory Sites
In the pre-genome era, most of what we knew about molecular evolution could be traced to our knowledge of the genetic code, and the impact of DNA sequence variation on protein structure and, by inference, protein function [1]. But in the post-genome era, it has become clear that the fraction of functional sequence— estimated using comparative approaches to identify residues that ‘‘escape’’ gene...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2013
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1003528